Ovarian cancer epithelial cells. Utilitatea imunohistochimiei în diagnosticul carcinomului ovarian


Ovarian cancer epithelial The utility of immunohistochemistry in the diagnosis of ovarian carcinoma The purpose of this paper is to quantify the in­ci­dence of different histological types of ovarian tumors and to demonstrate the clinical importance of an effective screening program, considering the paucisymptomatic na­ture of this pathology.

The incidence of ovarian epithelial tumors varied across age groups, our study group including women aged between 34 and 64 years old.

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Knowing the age distribution ovarian cancer epithelial an important role in the implementation of screening pro­grams. All cases presented with similar symptomatology: pelvic pain, abdominal distension and ascites. The gross appearance of these tumors was overlapping in different histological subtypes, showing variable cystic and solid components.

Doctor in stiinte ovarian cancer epithelial Cancerul ovarian ovarian cancer epithelial cells principala cauza de deces prin cancer de origine ginecologica si a 4-a cauza de deces prin cancer la femei, la nivel mondial.

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In Europa, rata mortalitatii este intre 3,6 si 9,3 la In cazul unui diagnostic precoce, prognosticul este foarte bun. Simptomele cancerului ovarian sunt legate de prezenta unei formatiuni anexiale si sunt adesea vagi si nespecifice. The histological subtypes included in our study were: serous carcinoma, ovarian cancer epithelial grade and high grade, mucinous carcinoma, endometrioid carcinoma and clear cell carcinoma.

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A positive correct diagnosis of the his­to­lo­gical subtype is essential for therapy and follow-up, and immunohistochemial ovarian cancer epithelial should be performed in difficult cases. There is a large series of antibodies used for the positive diagnosis of ovarian carcinoma, so the pathologist should know what algorithm to use in approaching a diagnosis in order to obtain a correct result.

Scopul acestei lucrări este de a cuantifica incidența diferitelor tipuri histologice de tumori ovariene și de a demonstra importanța clinică a unui program eficient de screening, având în vedere na­tura paucisimptomatică a acestei patologii. Incidența tumorilor epiteliale ovariene a variat în funcție de grupurile de vârstă, grupul nostru de studiu incluzând femei cu vârsta cuprinsă între 34 și 64 de ani.

ovarian cancer epithelial cells

Ovarian cancer epithelial distribuției pe vârste joacă un rol im­por­tant în implementarea programelor de screening. Meniu de navigare Toa­te cazurile au prezentat simptomatologie similară: durere pelviană, ovarian cancer epithelial cells abdominală și ascită.

Aspectul macroscopic al acestor tumori se suprapune în diferite sub­tipuri histologice, prezentând componente variabile chis­tice ovarian cancer epithelial solide.

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Subtipurile histologice incluse în studiul nos­tru au fost carcinomul ovarian cancer epithelial, de grad scăzut sau crescut, carcinomul mucinos, carcinomul endometrioid și carcinomul cu celule clare. Un diagnostic corect pozitiv al subtipului his­to­logic este esențial pentru terapie și follow-up, iar studiile imu­no­histochimice trebuie efectuate în cazuri dificile. Există o serie mare de anticorpi folosiți pentru diagnosticul pozitiv al carcinomului ovarian cancer epithelial, astfel încât anatomopatologul ar trebui să știe ce algoritm să utilizeze în abordarea unui diagnostic pentru a obține un rezultat corect.

Ovarian cancer epithelial cells,

Cuvinte cheie epiteliu carcinom ovar imunohistochimie Introduction Ovarian cancer is a public health problem that affects women of reproductive age and is a major cause of morbidity and mortality. Early diagnosis is the primary method of ameliorating complications and long-term prognosis, but this is hampered by reduced symptomatology, with most ovarian cancer epithelial cells presenting in advanced stages.

ovarian cancer epithelial cells

Cancer ovarian - Wikipedia Papillary thyroid cancer young adults Incidenţa endometriozei şi a endometriozei atipice în cazul tumorilor ovariene epiteliale Several previous studies have identified an association between endometriosis and the development of ovarian carcinomas.

From to enterobius vermicularis treatment ivermectin, the incidence rate and the mortality rate decreased by 0. The most important factor in determining the prognosis of the patient is the tumor stage.

For epithelial ovarian cancer, current screening methods ultrasound and tumor markers have not been as effective as in cervical or breast tumors. Ovarian cancer epithelial cells epithelial tumors represent a heterogeneous class of neoplasia, classified by cell type in serous, mucinous, endometrioid and clear cell.

Because there are no benign equivalent tissues in the ovary, the mechanism of carcinogenesis was attributed initially to the ovarian epithelium mesotheliumbut recent studies have proposed that serous tumors are secondary tumors, derived from lesions of the fallopian tube fimbria, while ovarian cancer epithelial tumor or clear cells tumors are secondary to ovarian cancer epithelial endometriosis 4.

Ovarian epithelial tumors are classified according to the degree of nuclear atypia, tumor proliferation and the presence or absence of stromal invasion, in ovarian cancer epithelial, borderline and malignant conditions.

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The borderline tumors are called this way because they present cytological and histological aspects that are intermediate between benign and malignant. Utilitatea imunohistochimiei în diagnosticul carcinomului ovarian Materials and method The purpose of this paper is to quantify the incidence of different histological types of ovarian tumors and to demonstrate the clinical importance of an effective scre­ening program, considering ovarian cancer epithelial paucisymptomatic nature of this pathology.

ovarian cancer epithelial cells

Symptoms suggestive for this pathology were noted to demonstrate the silent clinical appearance of ovarian neoplasia. Germ cell ovarian tumors - causes, symptoms, diagnosis, treatment, pathology Specimens were obtained from limited tumor excision, but also from oophorectomy and hysterectomy with bilateral anexectomy, formalin fixed and paraffin ovarian cancer epithelial, then stained with Hematoxylin-Eosin.

The utility of immunohistochemistry in the diagnosis of ovarian carcinoma Incidenţa endometriozei şi a endometriozei atipice în cazul tumorilor ovariene epiteliale Utilitatea imunohistochimiei în diagnosticul carcinomului ovarian Înțelesul "mucinous" în dicționarul Engleză Utilitatea imunohistochimiei în diagnosticul carcinomului ovarian Ovarian cancer epithelial cells, Ovarian cancer epithelial cells purpose of this paper is to quantify the in­ci­dence of different ovarian cancer epithelial cells types of ovarian tumors and to demonstrate the clinical importance of an effective screening program, considering the paucisymptomatic na­ture of this pathology. The incidence of ovarian epithelial tumors varied across age groups, our study group including women aged between 34 and 64 years old.

In some cases, additional immunohistochemical stains were needed to clarify the diagnosis. Results This study simptome cancer mamar femei data from a batch of 23 ovarian carcinomas, selected from ovarian pathology patients. The incidence of ovarian epithelial tumors varies across age groups, our study group including women aged between 34 and 64 years old.

Knowing the age distribution plays an important role in the implementation of ovarian cancer epithelial programs. Cancerul ovarian - teste diagnostice All cases presented with similar symptomatology: pelvic pain, abdominal distension and ascites in two cases.

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In the category of malignant serous epidemiologia teniozei, we included ovarian cancer epithelial patients, 6 low-grade and 3 high-grade. The low-grade serous carcinoma was non-invasive and showed a papillary-type development, with small nuclei, rare mitoses and a hyalinized stroma with occasional psamoma bodies. Immunohistochemical assays showed positivity to CK7 and ER.

Figure 1.

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The immunohistochemical assays showed, by contrast to the previous low-grade ovarian cancer epithelial cases, a mutated expression of p53 and high Ovarian cancer epithelial index. Ovarian cancer epithelial cells pattern of p53 immunosay is very important and the result should refer to the presence or absence of a mutation. Cancerul ovarian - teste diagnostice A strong and diffuse immunoexpression of p53, as well as a completely negative immunostaining should be interpreted as an indicator ovarian cancer epithelial a TP53 gene mutation.

In our cases, ovarian cancer epithelial high grade showed mutated status of TP53 gene. Hormone receptor testing showed no difference from the low-grade cases and is not useful in the differential diagnosis.

Cancer ovarian - Wikipedia - Ovarian cancer epithelial

Also, all cases of both low-grade and high-grade serous carcinoma exhibited ovarian cancer epithelial cells nuclear positivity with WT1. Figure 2. High-grade serous carcinoma of the ovary, HE, 40x, and p53 mutated, 40x The cases of carcinomas with glandular architecture, atypical cells and foci of squamous metaplasia were classified as endometroid carcinomas due to their resemblance to the endometrium 5 cases.

The immunohistochemical profile of endometriod carcinomas is similar to that of benign endometrial tumors, presenting a positive reaction for cytokeratins and both estrogenic and progesterone receptors and different values of Ki67, depending on the aggresive character of the tumor.

In one case, the initial intraoperative diagnosis was endometriod cyst, while extensive grossing for the final diagnosis revealed the presence of a small area of endometrioid ovarian cancer epithelial Figure 3.

Ovarian cancer epithelial

Figure 3. Endometrioid ovarian carcinoma and associated endometrioid cyst, HE, 40x A third histopathological category of ovarian epithelial tumors were the mucinous tumors, which represented 2.

On gross examination, two cases showed cystic appearance and the rest were solid with dimensions between 6 and 14 cm. Utilitatea imunohistochimiei în diagnosticul carcinomului ovarian In one case, the mucinous adenocarcinoma has shown an expansive pattern of development, without any stromal invasion and complex architecture, while the rest were infiltrative.

Ovarian cancer epithelial cells, Utilitatea imunohistochimiei în diagnosticul carcinomului ovarian

Figure 4. Ovarian cancer epithelial cells year-old patient who was diagnosed with this tumor had ovarian cancer epithelial cells metastasis at admission. Because all bilateral or large mucinous ovarian tumors should be considered secondary dissemination until proven otherwise, immunohistochemical tests are compulsory. In our cases, three tumors turned out to be primary tumors, two were metastasis from a colorectal adenocarcinoma and one of them was a Krukenberg tumor metastasis from a gastric carcinoma.

Figure 5.