Human papillomavirus prevention and treatment


Human papillomavirus prevention and treatment, Te-ar mai putea interesa şi …

It has been demonstrated that the human papil­loma­virus HPV type 16, a subtype of the human pa­pil­loma­virus, human papilloma virus human papillomavirus prevention and treatment se prenosi present in the oropharyngeal carcinomas of non-smokers patients inclusive.

HPV-infected cells express some viral proteins encoded by genes called E6 and E7, and can inactivate p53 protein and the retinoblastoma-type pro­tein RBP involved in the regulation of proliferation and cell death. Materials and method. We present an immunohistochemical study conducted to identify significant tumour markers in tonsillar SCC. We present the sta­tis­tically significant correlations between the presence of immunohistochemical human papillomavirus prevention and treatment and studied local re­cur­rence, lymph node recurrence and risk of a second can­cer human papillomavirus prevention and treatment the aerodigestive upper tract.

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HPV - Definiția și sinonimele HPV în dicționarul Engleză human papillomavirus prevention treatment The de­mon­stration of HPV in tonsillar tumour tissue requires in situ hybridization or polymerase chain reaction Human papillomavirus prevention treatment for the evidence of viral genome included into the host cell. The practical implications of an etiologic role of HPV in head and neck cancer generally and in tonsillar SCC in particular remains in question and is in relate with prog­nosis, treatment and prevention.

În afară de consumul de tutun şi abuzul de al­cool, anumite virusuri au fost asociate cu carcinomul cu celule scuamoase CCS al capului şi gâtului, cauzând al­te­rări la nivelul ADN-ului. Este dovedit că virusul papiloma uman HPVtipul 16, este prezent la nivelul carcinoamelor orofaringiene inclusiv în cazul nefumătorilor.

Conform datelor human papillomavirus prevention and treatment diverse studii se estimează o prevalenţă HPV globală de Alte tipuri HPV, cum ar fi 31, 33, 45, 58, 59 sunt mult mai human papillomavirus prevention and treatment raportate Papilomatoza laringiană se poate dezvolta atât la copil cât şi la adult. Human papillomavirus prevention and treatment respiratorie recurentă cu debut juvenil este cel mai frecvent neoplasm laringian benign la copii, fiind consecinţa infecţiei HPV transmise in utero sau la naştere de la o mamă cu infecţie cervicală curentă sau cu condiloame genitale La adult, incidenţa papiloamelor respiratorii este mai mică; pot fi localizate la nivelul laringelui predominantcavităţii orale, traheei, parenchimului pulmonar şi esofagului. Probele recoltate pe tampon uscat de la nivelul leziunilor anogenitale şi orale conţin celule exfoliate din care se poate extrage ADN şi efectua testul de genotipare HPV.

Celulele in­fec­ta­te cu HPV exprimă unele proteine virale codate de ge­ne­le denumite E6 şi E7 şi pot inactiva proteina p53 şi pro­tei­na de tip retinoblastom RBP implicate în reglarea pro­li­fe­ră­rii şi morţii celulare.

Materiale şi metodă. Pre­zen­tăm un stu­diu imunohistochimic realizat cu scopul de a identifica mar­keri tumorali semnificativi în CCS de amig­da­lă. Pre­zen­tăm co­re­la­ţiile semnificative statistic între prezenţa mar­ke­rilor imu­no­his­to­chimici şi recurenţa locală, recurenţa no­du­lilor limfatici şi ris­cul apariţiei unui al human papillomavirus prevention and treatment cancer în trac­tul aerodigestiv su­pe­rior.

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Punerea în evidenţă a HPV-ului în ţesutul tu­mo­ral amigdalian necesită hibridizare in situ şi reacţie de polimerizare în human papillomavirus prevention treatment PCR pentru punerea în evidenţă a genomului viral conţinut în celula-gazdă. Im­pli­caţiile practice ale unui rol etiologic al HPV-ului în can­ce­rele de cap şi gât, în general, şi în CCS human papillomavirus prevention treatment amigdală, în par­ti­cu­lar, reprezintă un subiect în human papillomavirus prevention treatment, fiind în relaţie cu prog­nos­ticul, tratamentul şi prevenţia acestor tipuri de can­cere.

Cuvinte cheie carcinomul cu celule scuamoase de amigdală CCS HPV markeri tumorali Introduction The tonsillar squamous cell carcinoma SCC is becoming a public de ce vin viermii problem because of its rising incidence in the last 20 years, in contrast human papillomavirus prevention and treatment the decreasing incidence of carcinomas in other subsites of head and neck human papillomavirus prevention treatment to the human papillomavirus prevention and treatment prevalence of smoking.

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These tumours of oral cavity, oropha­rynx, larynx, hypopharynx and sinonasal region are linked by common characteristics, including a male predominant appearance in the 5th-6th decade of life, an important etiological link with tobacco, alcohol use or betel nut chewing, and a histopathological resemblance 1. Data regarding the epidemiology revealed that in Romania the oropharyngeal cancer represents 2. In France, during the last 30 years, the mortality in oral and oropharyngeal cancer increased by three times 1.

As in cervical cancers, the oropharyngeal infection with HPV human papillomavirus prevention treatment a sexually transmitted disease which involves some particularities of sexual behaviour: a large number of vaginal sex partners, oral and anal sex.

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The recent increasing of OPSCC incidence may reflect the social changes regarding sexual behaviour in the modern world 6.

The anatomical sites preferred by HPV in oropharynx are the tonsils and the tongue, because of the unique presence of transitional mucosa in oropharynx and particular in tonsillar tissue, which presents important histological similarities with the cervical mucosa.

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Tonsillar epithelium invagination may favour virus capture and promote its access to basal cells the only dividing cells in the epithelium. The human papillomavirus prevention and treatment tissue could be a reservoir for HPV in the upper aero digestive tract. We human papillomavirus prevention treatment two premises for our study on tonsillar cancers.

The second consists in the fact that mutagens such as tobacco, alcohol and HPV viral oncogenes E6 and E7 induce dysfunctions of two major mechanisms of cellular cycle, which involves the p53 and RBP tumoral suppressor genes 2.

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  6. Condiloamele genitale sunt transmise prin contact sexual; aproximativ două treimi din persoanele care au contact sexual cu o persoană infectată vor dezvolta human papillomavirus prevention and treatment de leziuni, human papillomavirus prevention and treatment o perioadă de incubaţie variabilă 3 săptămâni — 8 luni 3.
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Materials and method We made an immunohistochemical retrospective study between andaiming to identify any correlations between tumoral markers and the evolution and prognosis in tonsillar SCC.

Materials We studied 52 cases of patients diagnosed with tonsillar SCC. We had a first group Group I with 25 cases, where the positive diagnose was made by biopsy and these patients had radiotherapy as first curative method of treatment.

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We had a second group Group II with 27 cases, where the positive diagnose was made on surgical specimens and these patients had surgery as the first curative method of treatment. The two groups were similar regarding age and gender distribution. The dilutions and markers specifications are revealed in Table 1. HPV prevention and vaccine information We also studied lymphocyte populations CD4, CD8, and populations of dendritic cells in tumour tissue.

Human papillomavirus prevention and treatment, Te-ar mai putea interesa şi …

Table 1. The dilutions and markers specifications Giardia klachten bij mensen the immunohistochemical identification of tumoral antigens we used the three-stadial indirect method Avidine-Biotine-Peroxidase ABPafter Hsu and colab.

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Results The gender repartition of cases was: 47 male cases and 5 female cases. The age repartition of cases was: two cases between years old, 14 cases between years old, 21 cases between years old, 10 cases between years old, and five cases between years old. The correlation coefficient between the two sets of data, corresponding to Group I and Group II, was 0.

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In both groups, we had 48 smoker patients, representing The patients who were both smokers and alcohol consumers represented We studied the tumoral markers on 52 cases of squamous cell carcinoma.

Thirty-eight cases were well differentiated carcinoma and 14 cases were medium differentiated carcinoma.

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We present the results, that we considered immunohistochemically valid and statistically significant Table 2. Table 2.

Human papillomavirus prevention and treatment

Înțelesul "HPV" în dicționarul Engleză The distribution of tumoral markers in specimens of SCC studied We realised a correlation between the presence of the tumoral marker of a certain type positive and slowly positive results and the post-therapeutic evolution — local recurrence, nodal relapse, the occurrence of second cancers in upper aerodigestive upper ways and distance metastases. We have had patients who had more than one recurrence in the same time.

Our purpose was to identify the correlations between markers of evolution and prognosis in tonsillar SCC. Our results indicate p53 protein and RBP protein as tumoral markers of unfavourable prognosis for post-therapeutic evolution in tonsillar SCC.

For TGFa, we can make a correlation between its level in tumoral tissue human papillomavirus prevention and treatment the risk of loco-regional relapse.

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For the HPV identification in tumoral tissue, we used the identification of capsid p16 protein, so we cannot make definitive conclusions referring at the presence or absence human papillomavirus prevention treatment HPV in the tumoral tissue for patients with tonsillar SCC.