Actualizări în tratamentul hormonal al cancerului de sân Cancer and hormones, Actualizări în tratamentul hormonal al cancerului de sân It is applied in patients expressing tumoral hormone receptors ER - estrogen receptor and PGR - progesteron receptor. It is possible that HER2 human epitelial growth factor receptor 2 to have an influence on the response or resistance to hormonal treatment.
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El cancer affecting hormones aplicat la pacientele la care se identifică în ţesutul tumoral prezenţa receptorilor hormonali ER - receptor estrogen şi PGR - receptor progesteron. Este posibil ca şi statusul HER2 receptorul 2 al factorului de creştere epidermal uman să aibă influenţă asupra răspunsului şi rezistenţei la cancer and hormones hormonal. Articolul are drept scop prezentarea principalelor clase de medicamente folosite în tratamentul hormonal şi cancer and hormones prinicipalelor indicaţii, progrese cancer affecting hormones şi perspective de viitor.
Cuvinte cheie tratament hormonal cancer de sân modulatori selectivi ai receptorului de estrogen inhibitori de aromatază Introduction Hormones are molecules that act like chemical messengers cancer affecting hormones the human body.
Their main circulating path is through the blood stream.
Estrogen and progesteron are made in the ovaries in premenopausal women, and in other tissues including fat in postmenopausal women. Apart from their classic role female sex characteristics, pregnancy etc.
To determine the hormonal status, tissue from the tumour is needed. It can be obtained either by biopsy, or by surgery. Main hormone therapy classes Blocking ovarian function - ovaries are the main production site of estrogen in premenopausal women. Blocking of their function can be achieved by either removing ovaries surgically, or by radiation both being definitive methods or, most frequently used today, inhibiting their function temporarily by using gonadotropin releasing hormone GnRH agonists or cancer affecting hormones hormone releasing hormone LH-RH agonists.
Traducere "sistemului endocrin" în engleză Axa hipotalamo-hipofizară reprezintă centrul de reglare al sistemului endocrin. The Hypothalamic-pituitary axis is the regulating centre of our endocrine system.
Examples: goserelin and leuprolide. The main side effects of these therapies are bone loss, mood swings, depression, and loss of libido.
Cancer and hormones
Blocking estrogen production - aromatase inhibitors AI cancer and hormones used to block the production of estrogens from fat and other tissues. They can be given alone in postmenopausal cancer and hormones or in association with ovarian suppression in premenopausal setting. Examples: anastrozole, letrozole - both inactivate temporarily the aromatase enzyme non-steroidal AI - or exemestane, which inactivates the enzyme permanently steroidal AI. Cancer and hormones.
Cancer affecting hormones
Actualizări în tratamentul hormonal al cancerului de sân The main side effects are: risk of heart attack, angina, heart failure, and hypercholesterolemia, bone loss, joint pain, mood swings and depression.
Blocking estrogens effects - two drugs block the action of estrogen on the breast tumour cells. Selective estrogen receptor modulating agents SERMs : they bind to the receptor, blocking it, thus preventing the binding of estrogen.
Examples: tamoxifen and toremifen. They act like antagonists in some tissues tumour cells and agonists in other uterus, boneinfluencing cancer affecting hormones safety profile. Common adverse reactions: risk of blood clots, especially in cancer affecting hormones lungs and legs, stroke, cataract, endometrial cancer, bone loss in premenopausal women. Other antiestrogen drugs, like fulvestrant: they act similarly to tamoxifen, but without the agonist effect.
Furthermore, after binding to the cancer and hormones receptor, they programme it for destruction. This explains the better safety profile and side effects: gastrointestinal symptoms, elevated liver functional tests, loss of strength and pain Taking into account the medical history of patients and other treatments they are undergoing, we must be paraziti cu iconi for interactions.
Traducere "sistemului endocrin" în engleză Axa hipotalamo-hipofizară reprezintă centrul de reglare al sistemului endocrin. The Hypothalamic-pituitary axis is the regulating centre of our endocrine system. In rare cases, fibrous dysplasia may be linked to abnormalities in the hormone-producing glands of the endocrine system.
Cancer and hormones, Actualizări în tratamentul hormonal al cancerului de sân
Datorita compozitiei cancer affecting hormones, propolisul prezinta efecte benefice asupra aparatului digestiv si sistemului endocrin; are proprietati antibacteriene si antivirale. Due to its composition, propolis shows beneficial effects on the digestive system and endocrine system ; It cancer and hormones antibacterial and antiviral properties.
For tamoxifen, caution must be taken for patients in treatment with antidepressants from the class of selective serotonin reuptake inhibitors SSRI like paroxetine, which inhibits enzyme CYP2D6.
They cancer affecting hormones down tamoxifen metabolization and reduce its effects. Safer alternatives are available, like sertraline, venlafaxine or even considering changing tamoxifen with AI.
Cancer affecting hormones Treatment protocols Prevention. The same indication for AI is still under investigation 8. There have been several studies investigating this option, mainly using AI.
The purpose is to obtain tumour shrinkage in order to allow breast conserving surgery. Although there are promising results, currently such therapies are not approved for this indication 9. Some studies show that patients with positive ER levels even with low count benefit from at least 5 years of therapy.
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Newer studies extend this period to 7 or cancer and hormones 10 years.